Bone Mechanobiology| Image Analysis| Bone Mechanics| Mechanotransduction| TMJ Biomechanics| Osteocytes

Research Grants Awarded

Current
1. NIH/NIAMS 1R01AR052461-01A2 (PI) 10/1/09-9/30/14 Mechanobiology of 3D Trabecular Bone Explants

2. NIH/NIAMS RC1AR058453-01 (PI) 10/1/09-9/30/11
Implicit Learning in Osteocyte Network under Mechanical Loading

3. NIH/NIDDK 2R01DK032333-24A2 (Co-Investigator, PI: John P. Bilezikian) 9/1/08-8/31/13 Primary Hyperparathyroidism

4. NIH/NIAMS 1R01 AR055647 (Co-Investigator, PI: Felix W. Wehrli) 12/01/07-11/30/11
$1,350,500 (TC)
$376,098 (Columbia Sub)
Osteoporosis Treatment Response Assessed by Micromechanical Modeling of MRI Data

5. NIH/NIAMS U01 AR 055068 (Co-Investigator, PI: Elizabeth Shane) 5/1/07-4/30/10
$724,500 (TC)
Ultra-high Resolution pQCT as a Biomarker of Bone Strength in Osteoporosis Trials

6. National Natural Science Foundation of China, Funds for Talented Professionals (Joint Research Fund for Overseas Chinese Young Scholars), 10628205 (PI) 1/1/2007-12/1/2009
¥400,000 (TC) (~$50,000)
Computational Models of Bone Adaptation

7. NIH/NIAMS R01 AR051376 (PI) 5/1/2006-4/30/2011
$3,087,709 (TC)
Micro-Mechanical Modeling of Trabecular Bone

8. NIH/NIAMS R01 AR053156 (Co-Investigator; PI of subcontract) (PI: Wehrli, Felix W. University of Pennsylvania, Bioengineering Research Partnership Grant) 9/23/2005-6/30/2010
$4,342,745
$422,896 (TC, Columbia Sub)
Structural MRI of Trabecular Bone in Monitoring Therapy

Pending
1. NIH/NIAMS 1R01AR058004-01 (PI) 10/1/09-9/30/14 Clinical Bone Mechanics Using HR-pQCT and µMRI

2. NIH/NIAMS 1R21ARXXXXX-01 (PI) 5/1/10-4/30/12 Pseudo-3D Cytoskeletal Dynamics and Signal Activation in Osteocytes under Flow

Completed
1. Whitaker Foundation 97-0086 (PI) 1/1/98-5/31/2001
$209,975 (TC )
Quantification of In Vivo Cellular Adaptation of Trabecular Bone by Mechanical Stimulation

2. NIH/NIAMS 1 R03 AR045832-01 (PI) 9/1/98-8/31/2001
$245,732 (TC)
Bone Response to Combined Mechanical and PTH Stimulation

3. NSF Faculty Early Career Development Award (PI) 7/1/99-6/30/2003
$220,000 (TC)
CAREER: An Efficient 3D Representation for Modeling Trabecular Bone Microstructure and Development of An Integrated Program in Computational Biomechanics

4. Whitaker Foundation TF 97-0086 (PI) 12/15/2001-12/14/2002
$80,000 (TC)
Gene Expression of Bone Cells in Response to Combined Mechanical and PTH Stimulation

5. NIH/NIAMS R01 AR048287 (PI) 5/1/2002-4/30/2007
$1,304,286 (TC)
Bone Response to Combined Mechanical and PTH Stimulation

6. NIH/NIAMS R21 AR048791 (Co-PI; PI: Hung, Clark T.) 3/1/2002-2/28/2005
$350,763 (TC)
Novel Determination of Chondrocyte Material Properties

7. NIH/NIAMS R01 AR049922 (Co-PI; PI: Hung, Clark T.) 9/26/1/2002-8/31/2007
$1,041,497 (TC)
Intervertebral Disc Response to Cyclic Loading In Vivo

8. NIH/NIAMS R21 AR049613 (PI) 9/30/2002-8/31/2006
$480,817 (TC)
Debonding Strength of Cement Lines in Human Cortical Bone

9. Schlumberger-Doll Research (PI) 12/07/2004-12/06/2006
$28,998 (TC)
Production of Bovine Trabecular Bone Samples and Mechanical Testing

10. NIH/NIAMS R21 AR052417 (PI) 5/1/2006-4/30/2008
$426,361 (TC)
Mechanotransduction in Osteocytic Network and Osteoblast

Notes
TC: Total cost
NIH: National Institutes of Health
NIAMS: National Institute of Musculoskeletal and Skin Diseases
NSF: National Science Foundation

Research Topics

Bone Mechanobiology

Cellular and Molecular Mechanisms of In Vivo Trabecular Bone Response to Mechanical and Hormonal Stimulation


Image Analysis

Contribution of Micro-Architecture in Elastic Modulus of Trabecular Bone


Bone Mechanics

- Micromechanics of Cortical Bone

- Determination of Interfacial Debonding Strength of Cement Lines


Mechanotransduction of Bone Cell Networks

TMJ Biomechanics

Pseudo-3D Imaging of Osteocytes

Our lab is studying the whole-cell mechanical behavior of osteocytes under dynamic fluid shear loading. By using a novel method to capture two orthogonal planes of the cell at a high frequency, termed pseudo-3D imaging, we are able to characterize the viscoelastic behavior of osteocytes under physiological loading frequencies and magnitudes.

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