2008-2009

1.    Sigmund, E. E., Cho, H., Chen, P., Byrnes, S., Song, Y.-Q., Guo, X. E., and Brown, T. R. (2008) Diffusion-based MR Methods for Bone Structure and Evolution, Magnetic Resonance in Medicine, 59(1):28¨C39.

2.    Liu, X. S., Sajda, P., Saha, P. K., Wehrli, F. W., Bevil, G., Keaveny, T. M., and Guo, X. E. (2008) Complete Volumetric Decomposition of Individual Trabecular Plates and Rods and Its Morphological Correlations with Anisotropic Elastic Moduli in Human Trabecular Bone, Journal of Bone Mineral Research, 23(2):223-235.

3.    Huo B., Lu, X. L., Hung, C. T., Costa, K. D., Xu, Q., Whitesides, G. M., and Guo, X. E. (2008) Fluid Flow Induced Calcium Response in Bone Cell Network, Cellular and Molecular Bioengineering, 1(1):58-66. (Cover Picture)

4.    Wan, L. Q., Jiang, J., Arnold, D. E., Guo, X. E., Lu, H. L., and Mow, V. C. (2008) Calcium Concentration Effects on the Mechanical and Biochemical Properties of Chondrocyte-Alginate Constructs, Cellular and Molecular Bioengineering, 1(1):93-102.

5.    Zhang, X. H., Liu, X. S., Branimir, V., Wehrli, F. W., Benito, M., Rajapakse, C. S., Snyder, P. J., and Guo, X. E. (2008) In Vivo µMRI Based Finite Element and Morphological Analyses of Tibial Trabecular Bone in Eugonadal and Hypogonadal Men before and after Testosterone Treatment, Journal of Bone Mineral Research, 23(9):1426-1434.

6.    Spalazzi, J. P., Dagher, E., Soty, S. B., Guo, X. E., Rodeo, S. A., and Lu, H. H. (2008) In Vivo Evaluation of a Multi-phased scaffold designed for Orthopaedic Interface Tissue Engineering and Soft Tissue-to-Bone Integration, Journal of Biomedical Materials Research, 86(1):1-12.

7.    Liu, X. S., Zhang, X. H., Huang, A. H., Sajda, P., Ji, B., and Guo, X. E. (2008) Dynamic Simulation of 3D Architectural and Mechanical Alterations in Human Trabecular Bone during Menopause, Bone, 43(2):292-301.

8.    Li, C. Q., Magland, J. M., Rajapakse, C. S., Guo, X. E., Zhang, X. H., Wehrli, F. W. (2008) Implications of Resolution and Noise for In Vivo Micro-MRI of Trabecular Bone, Medical Physics, 35(12):5584-5594.

9.    Shi, Y, Yadav, Y., Suda, N., Liu, X. S., Guo, X. E., Myers, M. and Karsenty, G. (2008) Dissociation of the Neuronal Regulation of Bone Mass and Energy Metabolism by Leptin In Vivo, Proceedings of National Academies of Science, 105(51):20529-20533.

10.    Liu, X. S., Bevil, G., Keaveny, T. M., Sajda, P., and Guo, X. E. (2009) Micromechanical Analyses of Vertebral Trabecular Bone Based on Complete Volumetric Decomposition of Individual Trabecular Plates and Rod, Journal of Biomechanics, 40(2):249-256.

11.    Lu, X. L., Mow, V. C., and Guo, X. E. (2009) Proteoglycans and Mechanical Behaviors of TMJ Condylar Cartilage, Journal of Dental Research, 88(3):244-248.

12.    Liu, X. S., Zhang, X. H., and Guo, X. E. (2009) Contributions of Trabecular Rods of Various Orientations in Determining the Elastic Properties of Human Vertebral Trabecular Bone, Bone, 45(2):158-163 (Cover picture).

13.    Yadav, V. K., Oury, F., Suda, N., Liu, Z., Gao, X., Confavreux, C. Klemenhagen, K. C., Tanaka, K. F., Gingrich, J. A., Guo, X. E., Tecott, L. H., Mann, J. J., Hen, H., Horvath, T. L., and Karsenty, G. (2009) A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure, Cell, 138:976¨C989.

14.    Rajapakse, C. S., Magland, J., Zhang, X. H., Liu, X. S., Wehrli, S. L., Guo, X. E., and Wehrli, F.W. (2009) Implications of Noise and Resolution on Mechanical Properties of Trabecular Bone Estimated by Image-based Finite-Element Analysis, Journal of Orthopaedic Research, 27(10):1263-1271.

15.    Chan, M. E., Lu. X. L., Huo, B., Baik, A. D., Chiang, V., Guldberg, R. E., Lu, H. H., and Guo, X. E. (2009) A Trabecular Bone Explant Model of Osteocyte-Osteoblast Co-Culture for Bone Mechanobiology, Cellular and Molecular Bioengineering, 405-415.

16.    Cohen, A., Dempster, D. W., M¨¹ller, R., Guo, X. E., Nickolas, T. L., Liu, X. S., Zhang, X. H., Wirth, A. J., van Lenthe, G. H., Kohler, T., McMahon, D. J., Zhou, H., Rubin, M. R., Bilezikian, J. P., Lappe, J. M., Recker, R.R. and Shane E. Assessment of Trabecular and Cortical Architecture and Mechanical Competence of Bone by High-Resolution Peripheral Computed Tomography: Comparison with Transiliac Bone Biopsy, Osteoporosis Intl., in press, 2009.

17.    Cohen, A., Liu, X. S., McMahon, D. J., Rogers, H. F., LeMaster, J., Recker, R. R., Lappe, L. L., Guo, X. E., and Shane, E. Bone Microachitecture and Trabecular Bone Elastic Stiffness in Premenopausal Women with Idiopathic Osteoporosis, The Journal of Clinical Endocrinology & Metabolism, in press, 2009.

18.    Liu, X. S., Zhang, X. H., Sekhon, K. K., Admas, M. F., McMahon, D. J., Shane, E., Bilezikian, J. P., and Guo, X. E. High-Resolution Peripheral Quantitative Tomography Can Assess Microstructural and Mechanical Properties of Human Distal Tibial Bone, Journal of Bone and Mineral Research, in press, 2009.

19.    Fang, G., Ji, B., Liu, X. S., and Guo, X. E. Quantification of Trabecular Bone Microdamage Using the Virtual Internal Bond Model and the Individual Trabeculae Segmentation Technique, Computational Methods in Biomechanics and Biomedical Engineering, in press, 2009.

20.    Huo, B. Lu, X. L., Costa, K. D., Xu, Q. and Guo, X. E. Intracellular Calcium Wave Propagation in Linear and Looped Bone Cell Network under AFM Stimulation, Proceedings of the Royal Society A, in press, 2009.

21.    Grayson, W. L., Fröhlich, M., Yeager, K., Bhumiratana, S., Chan, M. E., Cannizzaro, C., Wan, L. W., Liu, X. L., Guo, X. E., and Vunjak-Novakovic, G. Engineering Anatomically-Shaped Human Bone Grafts: The Role of Medium Perfusion, Proceedings of National Academy of Science, in press, 2009.

22.    Liu, X. S., Cohen, A. McMahon, D. J., Lappe, J. M., Recker, R. R., Shane, E. and Guo, X. E., Individual Trabeculae Segmentation (ITS)-Based Morphological Analyses Can Detect Abnormal Microarchitecture of Plate- and Rod-Like Trabeculae in Premenopausal Women with Idiopathic Osteoporosis, Journal of Bone and Mineral Research, in press, 2009.

23. Lu, X. L., Wan, L. Q., Guo, X. E., and Mow, V. C. A Linearized Formulation of Triphasic Mixture Theory for Articular Cartilage, and Its Application to Indentation Analysis, J Biomechanics, in press, 2009.

2006-2007

24.    Takai, E., Landersberg, R., Katz, R. W., Hung, C. T. and Guo, X. E. (2006) Osteoblast Cell Adhesion Strength and Focal Adhesion Kinase Activation on Various Substrates, Molecular and Cellular Biomechanics, 3(1):1-12.

25.    Dong, X. N., and Guo, X. E. (2006) Prediction of Cortical Bone Stiffness Using a Generalized Self-Consistent Method, ASME Journal of Biomechanical Engineering, 128(3):309-16.

26.    Ishii, Y., Thomas, A. O., Lawler, J., Guo, X. E., Ateshian, G. A., Hung, C. T., and Chen, F. H. (2006) Localization and Distribution of Cartilage Oligomeric Matrix Protein in the Rat IVD, Spine, 31(14):1539-46.

27.    Ho, M. M., Kelly, T. N., Guo, X. E., Ateshian, G. A., and Hung, C. T. (2006) Spatially Varying Material Properties of the Rat Caudal Intervertebral Disc, Spine, 31(15):E486-93.

28.    Liu, X. S., Sajda, P., Saha, P. K., Wehrli, F. W., and Guo, X. E. (2006) Quantification of the Roles of Trabecular Micro-architecture and Trabecular Type in Determining the Elastic Modulus of Human Trabecular Bone, Journal of Bone and Mineral Research, 21(10):1608-1617.

29.    Guo, X. E., Takai, E., Jiang, X., Xu, Q., Whitesides, G. M., Yardley, J. T., Hung, C. T., Chow, E. M., and Costa, K. D. (2006) Intracellular Calcium Waves in Bone Cell Networks Under Single Cell Nanoindentation, Molecular and Cellular Biomechanics, 3(3):95-107.

30.    Freed, L. E., Guilak, F., Guo, X. E., Gray, M. L., Tranquillo, R., Holmes, J. W., Radisic, M., Sefton, M. V., Kaplan, D., and Vunjak-Novakovic, G. (2006) Advanced Tools: Scaffolds, Bioreactors, Signaling, Tissue Engineering, 12(12):3285-3305.

31.    Lu, X. L., Miller, C., Chen, F. H., Guo, X. E., and Van C. Mow (2007) Application of the Generalized Triphasic Correspondence Principle for Simultaneous Determination of the Mechanical Properties and Proteoglycan Content of Articular Cartilage by Indentation, Journal of Biomechanics, 40(11):2434-2441.

32.    Kim, C. H., X. Henry Zhang, Mikhail, G. von Stechow, D., M¨¹ller, R. Han Sung Kim, and Guo, X. E. (2007) Effects of Thresholding Techniques on µCT Image Based Finite Element Models of Trabecular Bone, ASME Journal of Biomechanical Engineering, 129(4):481-486.

2004-2005

33.    Chua, S. C. Jr., Liu, S. M., Li, Q., Sun, A., DeNino, W. F., Heymsfield, S.B., and Guo, X. E. (2004) Transgenic Complementation of Leptin Receptor Deficiency. II. Increased Leptin Receptor Transgene Dose Effects on Obesity/diabetes and Fertility/lactation in Lepr-db/db mice, Am. J. Physiol. Endocrinol. Metab., 286(3):E384-392.

34.    Sun, D. D., Guo, X. E., Likhitpanichkul, M., Lai, W. M. and Mow, V.C. (2004) The Influence of the Fixed Negative Charges on Mechanical and Electrical Behaviors of Articular Cartilage under Unconfined Compression, ASME J Biomech. Eng., 126:6-16.

35.    Lu, L., Sun, D. D. N. Guo, X. E., Chen, F. H., Lai, W. M., and Mow, V. C. (2004) Indentation Determined Mechanoelectrochemical Properties and Fixed Charge Density of Articular Cartilage, Ann. Biomed. Eng. 32(3):370-379.

36.    Wan, L. Q., Miller, C., Guo, X. E., and Mow, V. C. (2004) Fixed Electrical Charges and Mobile Ions Affect the Measurable Mechano-Electrochemical Properties of Charged-Hydrated Biological Tissues: The Articular Cartilage Paradigm, Mechanics and Chemistry of Biosystems, 1(1):81-99.

37.    Dong, X. N. and Guo, X. E. (2004) The dependence of transversely isotropic elasticity of human femoral cortical bone on porosity, J. Biomech., 37:1281-2187.

38.    Takai, E., Mauck, R. L., Hung, C. T. and Guo, X. E. (2004) Osteocyte Viability and Regulation of Osteoblast Function in a 3D Trabecular Bone Explant under Dynamic Hydrostatic Pressure, Journal of Bone and Mineral Research, 19(9):1403-1410.

39.    Dong, X. N. and Guo, X. E.  (2004) Geometric Determinants to Cement Line Debonding and Osteonal Lamellae Failure in Osteon Pushout Tests, ASME J. Biomech. Eng., 126(3):387-390.

40.    Dong, X. N., Zhang, X. H., Huang, Y. Y., and Guo, X. E. (2005) A Generalized Self-consistent Estimate for the Effective Elastic Moduli of Fiber-reinforced Composite Materials with Multiple Transversely Isotropic Inclusions, Int. J. Mech. Eng., 47:922¨C940.

41.    Takai, E., Costa, K. D., Shaheen, A., Hung, C. T., and Guo, X. E. (2005) Osteoblast Elastic Modulus Measured by Atomic Force Microscopy is Substrate Dependent, Annals of Biomedical Engineering, 33(7):963¨C971. (Cover Picture)

42.    Dong, X. N., Zhang, X., and Guo, X. E. (2005) Interfacial Strength of Cement Lines in Human Cortical Bone, Mechanics and Chemistry of Biosystems, 2(2):63-68.

43.    Lu, H. H., Jiang, J., Tang, A., Hung, C. T., and Guo, X. E. (2005) Development of Controlled Heterogeneityy on a Polymer-Ceramic Hydrogel Scaffold for Osteocondral Repair, Key Engineering Materials, 284-286:607-610.

44.    Xu, X. L., Tang, T., Dai, K., Zhu, Z., Guo, X. E., Yu, C., Lou, J. (2005) Immune Response and Effect of Adenovirus-mediated Human BMP-2 Gene Transfer on the Repair of Segmental Tibial Bone Defects in Goats, Acta Orthopaedica, 76(5):637-646.

45.    Hoffler, C. E., Guo, X. E., Zysset, P. K., and Goldstein, S. A. (2005) An Application of Nanoindentation Technique to Measure Bone Tissue Lamellae Properties, ASME J. Biomech. Eng., 127(7):1046-1053.

46.    Likhitpanichkul, M., Guo, X. E., and Mow, V. C. (2005) Tension-Comprression Nonlinearity Influences the Mechano-Electrochemical Environment of Chondrocytes in Cartilage under Unconfined Compression, Molecular and Cellular Biomechanics, 2(4):191-204.

2000-2003

47.    Guo, X. E. and Goldstein, S. A. (2000) Vertebral Trabecular Lamellar Modulus Does Not Change in Ovarietomized Rats, J. Orthop. Res., 18:333-336.

48.    Schaffner, G., Guo, X. E., Silva, M. J. and Gibson, L. J. (2000) Modeling Fatigue Damage Accumulation in Two-Dimensional Voronoi Honeycombs, Intl. J. Mech. Eng., 42:645-656.

49.    Guo, X. E., and Kim, C. H. (2002) Mechanical Consequence of Bone Loss and Treatment in Trabecular Bone: A 3D Microstructural Model, Bone, 30:404-411.

50.    Guo, X. E., Eichler, M. J., Takai, E. and Kim, C. H. (2002) A Rat Tail Vertebrae Model for Trabecular Bone Adaptation Studies, J. Biomech. 35:363-368.

51.    Lai, W. M., Sun, D. D., Ateshian, G. A., Guo, X. E. and Mow, V. M. (2002) Electrical Signals for Chondrocytes in Cartilage, Biorheology, 39(1/2):11-25.

52.    Wang, C. C.-B., Guo, X. E., Sun, D. D., Mow, V. C., Ateshian, G. A., and Hung, C. T. (2002) The Functional Environment of Chondrocytes within Cartilage Subjected to Compressive Loading: Theoretical and Experimental Approach, Biorheology, 39(1/2):39-45.

53.    Mow, V. C. and Guo, X. E. (2002) Mechano-Electrochemical Properties of Articular Cartilage: Their Inhomogeneities and Anisotropies, Annual Review in Biomedical Engineering, 4:175-209.

54.    Kim, C. H., Takai, E., Zhou, H., von Stechow, D., M¨¹ller, R., Dempster, D. W. and Guo, X. E. (2003) Trabecular Bone Response to Mechanical and Parathyroid Hormone Stimulation: The Role of Mechanical Microenvironments, J. Bone and Miner. Res., 18(12):2116-2125.

55.    Hung, C. T., Lima, E G., Mauck, R. L., Takai E., LeRoux, M. A., Lu, H. H., Stark, R. G., Guo, X. E., and Ateshian, G. A. (2003) Anatomically Shaped Osteochondral Constructs for Articular Cartilage Repair, J. Biomemch., 36(12):1853-1864.

Before 2000

56. Guo, X. and Wu, W-Y (1987) The Stokes Flow Produced by An Arbitrary Axisymmetric Oblate Body Moving Perpendicularly Toward An Infinite Flat Wall Along Its Minor Axis, Acta Scientiarum Naturalium Universitatis Pekinensis, 1:39-48.

57. Guo, X. and Wu, W-Y (1988) An Approach to the Mathematical Modeling of the Pulse Condition-the Displacement Wave, (Chinese) Journal of Biomechanics, 3(1):21-26.

58. Guo, X. and Wu, W-Y (1988) The Mathematical and Mechanical Models in Biomechanics of the Spine: Review, Foreign Medicine: Biomedical Engineering (P. R. China), 11(6):296-301.

59. Wu, W-Y, Liang, L. and Guo, X. (1990) The Mixed Finite Element Method for Axisymmetric Stokes Flow on the Unbounded Domains. Chinese Journal of Computational Physics, 7(3):294-302.

60. Guo, X. and Wu, W-Y (1991) Mechanical Analysis of Correction of Scoliosis by Means of Shape Memory Alloy Rods --- Simple Mathematical and Mechanical Model, Chinese Journal of Biomedical Engineering, 10(2):87-93.

61. Guo, X. and Cowin, S. (1992) Periosteal and Endosteal Control of Bone Remodeling Under Torsional Loading, J. Biomechanics, 25:645-650.

62. Michel, M. C., Guo, X. E., Gibson, L. J., McMahon, T. A. and Hayes, W. C. (1993) Compressive Fatigue Behavior of Bovine Trabecular Bone, J. Biomechanics, 26:453-463.

63. Guo, X. E., Gibson, L. J., McMahon, T. A., Keaveny, T. M. and Hayes, W. C. (1994) Finite Element Modeling of Damage Accumulation in Trabecular Bone Under Cyclic Loading, J. Biomechanics, 27:145-155.

64. Keaveny, T. M., Guo, X. E., Watchtel, E. F., McMahon, T. A. and Hayes, W. C. (1994) Trabecular Bone Exhibits Fully Linear Elastic Behavior and Yields at Low Strains, J. Biomechanics, 27:1127-1136.

65.    Keaveny, T. M., Watchtel, E. F., Guo, X. E. and Hayes, W. C. (1994) The Mechanical Properties of Damaged Trabecular Bone, J. Biomechanics, 27:1309-1318.

66.    Gulberg, R. E., Caldwell, N. J., Guo, X. E., Goulet, R. W. and Goldstein, S. A. (1997) Mechanical Stimulation of Tissue Repair in the Hydraulic Bone Chamber, J. Bone Miner. Res., 12:1295-302.

67.    Guo, X. E. and Goldstein, S. A. (1997) Is trabecular Bone Tissue Different from Cortical Bone Tissue? Forma, 12:185-196.

68.    Guo, X. E., Liang, L. C. and Goldstein, S. A. (1998) Micromechanics of osteonal cortical bone fracture, J. Biomech. Eng., 120:112-117.

69.    Bowman, S. M., Guo, X. E., Cheng, D. W., Keaveny, T. M., Gibson, L. J., Hayes, W. C. and McMahon, T. A. (1998) Creep Contributes to the Fatigue Behavior of Bovine Trabecular Bone, J. Biomech. Eng., 120:647-654.

70.    Guo, X. E., and Gibson, L. J. (1999) Behavior of Intact and Damaged Honeycombs: A Finite Element Study, Intl. J. Mech. Eng., 41:85-105.

71.    Zysset, P.K., Guo, X.E., Hoffler, C.E., Moore, K.E. and Goldstein S.A. (1998) Mechanical properties of human trabecular bone lamellae quantified by nanoindentation, Technology and Health Care, 6:429-432.

72.    Sun, D. N., Gu, W. Y., Guo, X. E., Lai, W. M. and Mow, V. C. (1999) A Mixed Finite Element Formulation of Triphasic Mechano-electrochemical Theory for Charged, Hydrated Biological Soft Tissues, Int. J. Num. Methods Eng., 45:1375-1402.

73.    Zysset, P. K., Guo, X. E., Hoffler, C. E., Moore, K. E. and Goldstein, S. A. (1999) Elastic Modulus of Human Cortical and Trabecular Tissue Lamella, J. Biomech., 32:1005-1012.

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